study reveals sars-cov-2 rna cap structure

Emerging coronaviruses: Genome structure replication

Emerging coronaviruses: Genome structure replication and pathogenesis Yu Chen Corresponding Author E-mail address: chenyuwhu edu cn State Key Laboratory of Virology Modern Virology Research Center College of Life Sciences Wuhan University Wuhan China Correspondence Yu Chen Modern Virology Research Center College of Life Sciences Wuhan University Wuhan 430072

The Genome Sequence of the SARS

We sequenced the 29 751-base genome of the severe acute respiratory syndrome (SARS)–associated coronavirus known as the Tor2 isolate The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses including two human coronaviruses HCoV-OC43 and HCoV-229E Phylogenetic analysis of the predicted viral proteins indicates that the virus does not


High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA Pieter Mestdagh 1 Center for Medical Genetics Ghent University Hospital 9000 Ghent Belgium and 2 Applied Biosystems Foster City 94404 CA USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Pieter Mestdagh Tom Feys 1 Center for Medical Genetics

SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily

Coronavirus entry requires its binding to host cell receptor ACE 2 and subsequent priming by TMPRSS 2 Using unpublished single‐cell data of the human lung and bronchia this study reveals expression of potential SARS ‐CoV‐2 cofactors ACE 2 TMPRSS 2 and FURIN primarily in bronchial cells transitioning from secretory to ciliated identity

Functional screen reveals SARS coronavirus nonstructural

Although the final cap structures of viral and cellular mRNAs are similar some RNA viruses adopt unique biochemical mechanisms to build the cap structure (2–4) Coronaviruses are the etiological agents of respiratory and enteric diseases in humans and livestock exemplified by the life-threatening severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) ( 5 )


on the study published via the National Health Commission of the People's Republic of China (4) So the emerging virus rapidly becomes a challenge for global public health This comprehensive review paper presents the latest information about characteristics diagnostic methods immunopathogenesis and clinical manifestations of SARS-CoV-2 Characteristics of SARS -CoV 2 Initially in 1966

Emerging coronaviruses: Genome structure replication

Emerging coronaviruses: Genome structure replication and pathogenesis Yu Chen Corresponding Author E-mail address: chenyuwhu edu cn State Key Laboratory of Virology Modern Virology Research Center College of Life Sciences Wuhan University Wuhan China Correspondence Yu Chen Modern Virology Research Center College of Life Sciences Wuhan University Wuhan 430072

Glecaprevir and Maraviroc are high

In a recent study MVC is recommended as a potential drug The crystal structure of SARS-CoV-2 M pro in complex with different inhibitors provide a basis to identify potential inhibitors We have extensively analyzed the available crystal structures of SARS-CoV-2 M pro including the PDB IDs 5R7Y 5R7Z 5R80 5R81 5R83 5R84 5RE4 5RE9 5REB 5RF1 5EFQ 6LU7 and 6W63 and investigated

PRACE Awards Ten Further Projects in Hunt for a COVID

Several projects make the structure and screening results of targets in the virus such as 3CLpro Spike nsp1 RNA-dependent RNA polymerase etc visible clarify their functions and how they can be blocked with various compounds and tools To find all these answers and to make new discoveries scientists need to use different libraries with tens of millions of compounds including ZINK drug

Baloxavir marboxil

Baloxavir marboxil (BXM) sold under the brand name Xofluza is an antiviral medication for treatment of influenza A and influenza B flu It was approved for medical use in Japan and in the United States in 2018 and is TongWein as a single dose by mouth It may reduce the duration of flu symptoms by about a day but is prone to selection of resistant mutants that render it ineffectual

Australian Biotech Company News

Australian Biotech Company News What Do Biotechnology Companies Do? Biotechnology is the application of biology (the study of living organisms) to a technological outcome The companies involved in this ground-breaking and rapidly evolving industry are seeking to profit from their innovation in a variety of fields These areas include


The pharmacological reduction of nsp16 2′-O-MTase activity can disrupt the 2′-O-methylation in the RNA cap structure and promote the accumulation of cap-0 structures with lower efficiency of translation thereby suppressing the synthesis of viral proteins while the viral RNA lacking a cap-1 structure can be recognized by innate RNA sensors and stimulate an early type I interferon response

Immunology of COVID

Increasingly studies are being published that provide evidence for the tropism of SARS-CoV-2 to tissues outside the respiratory system – i e the affinity of SARS-CoV-2 to infect organs besides the lungs (Chu et al 2020 Xiao Tang et al 2020) Of note a postmortem study of six patients who died of COVID-19 revealed that the novel coronavirus has the potential to infect the secondary


Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for drug discovery However this approach has mainly focused on the stabilization of native PPIs and non-native PPIs have received little consideration Here we identified a non-native interaction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV


Orthocoronavirinae comnmente conocidos como coronavirus es una subfamilia de virus ARN monocatenario positivos perteneciente a la familia Coronaviridae Se subdivide en los gneros Alphacoronavirus Betacoronavirus Gammacoronavirus y Deltacoronavirus [2] [3] Estos incluyen genogrupos filogenticamente similares de virus con una nucleocpside de simetra helicoidal con

Computational analysis of microRNA

SARS-CoV-2 a positive-single stranded RNA (+ssRNA) virus with exceptionally large genome with 5′cap structure and 3′polyA tail belongs to β CoV with 45-90% genetic similarity to SARS-CoV based on sequence analysis and might share similar viral genomic and transcriptomic complexity (Deng Peng 2020 Chen Liu Guo 2020) SARS-CoV-2 encodes nonstructural proteins while others code for

Profile Department of Biochemistry University of Otago

Research Kurt Krause is a Professor of Biochemistry at the University of Otago He has a longstanding interest in structure and function in biology and his research areas include the structure and function of enzymes and proteins important in infectious diseases such as bacterial pathogenesis factors antibiotic targets viral immunomodulatory proteins and bioluminescence related proteins

Rhiju Das' Profile

RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look RNA (New York N Y ) Rangan R Zheludev I N Das R 2020 Abstract As the COVID-19 outbreak spreads there is a growing need for a compilation of conserved RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to guide development of antivirals and

Coronaviridae – Wikipedia

Die Coronaviridae umgangssprachlich auch Coronaviren genannt sind eine Virusfamilie innerhalb der Ordnung Nidovirales Ihre Vertreter verursachen bei verschiedenen Wirbeltieren wie Sugetieren Vgeln und Fischen sehr unterschiedliche Erkrankungen Die ersten Coronaviren wurden bereits Mitte der 1960er Jahre beschrieben Coronaviren sind genetisch hochvariabel einzelne Arten aus der

Zinc finger

History Zinc fingers were first identified in a study of transcription in the African clawed frog Xenopus laevis in the laboratory of Klug A study of the transcription of a particular RNA sequence revealed that the binding strength of a small transcription factor (transcription factor IIIA TFIIIA) was due to the presence of zinc-coordinating finger-like structures

MicroRNAs: Novel Biomarkers for Human Cancer

MicroRNAs: Novel Biomarkers for Human Cancer Claudine L Bartels Department of Pathology Dartmouth Medical School Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center Lebanon NH USA Search for other works by this author on: Oxford Academic Google Scholar Claudine L Bartels Gregory J Tsongalis Department of Pathology Dartmouth Medical School


The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate Because of their unique specificity and essential role in viral polyprotein processing these proteases are suitable targets for the development of antiviral drugs In order to obtain near-equipotent broad

Genetics Genomics Molecular Diagnostics News by

GenomeWeb is an online news organization serving the global community of scientists technology professionals and executives who use and develop the latest advanced tools in molecular biology research and molecular diagnostics Covering Genetics News Genome DNA and more

Upinder Singh's Profile

In this study RNA-Seq data was utilised to define basal transcriptional control elements as well as to identify promoters which regulate stage-specific gene expression patterns We discovered that the 5' and 3' untranslated regions of E invadens genes are short a median of 20 nucleotides (nt) and 26 nt respectively Bioinformatics analysis of DNA sequences proximate to the start and stop


COVID-19 A newly identified beta-coronavirus denoted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a cluster of pneumonia cases in Wuhan China in December 2019 1–5 The disease caused by SARS-CoV-2 was subsequently named by WHO as COVID-19 Genome sequencing of SARS-CoV-2 showed that the virus is closely related (with 88% identity) to two bat-derived SARS

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